1519 · Indigenousyear only
Smallpox reaches the Antilles in the year Enriquillo goes to the hills
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Smallpox arrived in the Greater Antilles in 1519 and killed a large part of the indigenous population that forced labour had not already destroyed. The disease had never been in the Americas. Nobody carried immunity, whole households fell ill at the same time so that no one was well enough to fetch water, and mortality in the first outbreak was catastrophic. From Hispaniola the infection ran on to the mainland ahead of the Spanish armies, which is why Cortes found Mexico already weakened. In the same year a cacique named Enriquillo, raised in a Spanish monastery and himself holding an encomienda grant, refused to accept the treatment of his people by the colonist with authority over them. He led the men and women under him into the Bahoruco mountains in the southwest of the island and stayed there. The Spanish could not dislodge him. Fourteen years of raids and stalemate followed before the crown offered terms.